ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of anti-HIV III B virus with extractions from Juglans regia, so as to searching for the new and efficacious leading compound of AIDS therapy.</p><p><b>METHOD</b>Phytochemical and chromatographical techniques were used to isolate compounds from J. regia; MT4 cells and HIV III B virus were used to study the effect of anti-HIV activity in vitro. BIACORE 3000 molecule coupled equipment were used for the target research also.</p><p><b>RESULT</b>Two extractions (B&E) were isolated from J. regia which possess the effect of anti-HIV activity. Targets study found that extraction B could affected on HIV-1 gp-41 fusing protein and extraction E could affected on HIV-1 integrase respectively.</p><p><b>CONCLUSION</b>J. regia is a traditional Chinese medicine with active anti-HIV activity and worth to be studied further.</p>
Subject(s)
Humans , Cell Line , Drugs, Chinese Herbal , Chemistry , Pharmacology , HIV-1 , Juglans , Chemistry , Plant Extracts , Chemistry , PharmacologyABSTRACT
This paper summarized the recent 6 years' progress of anti-HIV compounds and traditional Chinese medicines by searching international network and reviewing the domestic and foreign literature. Traditional Chinese medicinal appeared to be a rich source of potentially useful materials for the treatment of human immunodeficiency virus infection. Some of them are much more potent in anti-HIV activity. And some components extracted from the herbs are even more tonic than the crude herb medicines. It has been proved that some active components such as alkaloids, proteins, flavonoids, quercetin, terpene, lignanoid are able to work on anti-HIV. People should pay more attention to the study of traditional Chinese medicine and the leading compounds on anti-HIV/AIDS in the clinic and in the laboratory. So searching for high efficacy and low toxicity anti-HIV drug from traditional Chinese medicine is an important and prospective research direction in the future.
Subject(s)
Animals , Humans , Acquired Immunodeficiency Syndrome , Drug Therapy , Adjuvants, Immunologic , Pharmacology , Anti-HIV Agents , Pharmacology , Drugs, Chinese Herbal , Pharmacology , Therapeutic Uses , HIV , Medicine, Chinese Traditional , Phytotherapy , Plants, Medicinal , ChemistryABSTRACT
<p><b>OBJECTIVE</b>To investigate the pharmacological function of Sanshengwan decoction with modern medical and rheological techniques, and also to discuss the differences between injury blood stasis syndrome and yang deficiency blood stasis syndrome.</p><p><b>METHOD</b>Animal model for injury blood stasis syndrome was found by bruise; Animal model for yang deficiency blood stasis syndrome was done by exhausting the animals in a - 15 degrees C freezer for 4 hours.</p><p><b>RESULT</b>Blood fibrinogen content, platelet aggregation and blood coagulation time were significantly increased, plasma viscosity and blood coagulation slope was significantly decreased in injury blood stasis syndrome group. Blood fibrinogen content, platelet aggregation and blood coagulation time were dropped markedly. Blood coagulation slope was raised noticeably in yang deficiency blood stasis syndrome group. Sanshengwan decoction behaved very good effects on removing blood stasis on both of the two kinds of animal models.</p><p><b>CONCLUSION</b>Though hemorheological index and experimental data in the two kinds of animal models were behaved statistically significance, but the experimental representative indexes were obviously difference. Sanshengwan the tipical herbal medicine for eliminating blood stasis syndrome showed significantly effects on both of the two kinds of animal models, but the effects on injury blood stasis syndrome group was better than the other animal model's.</p>
Subject(s)
Animals , Male , Rats , Angelica sinensis , Chemistry , Blood Viscosity , Drug Combinations , Drugs, Chinese Herbal , Pharmacology , Fibrinogen , Metabolism , Hemorheology , Medicine, Chinese Traditional , Paeonia , Chemistry , Plants, Medicinal , Chemistry , Platelet Aggregation , Rats, Wistar , Wounds and Injuries , Blood , Yang Deficiency , BloodABSTRACT
<p><b>OBJECTIVE</b>To evaluate the therapeutic effect of QuDu ZengNing Capsule on AIDS.</p><p><b>METHODS</b>QuDu ZengNing Capsule is a capsule containing extract from 4 Chinese medicinal herbs. Totally 1,000 AIDS patients were treated, among them 60 patients were clinically observed weekly. Blood routine tests, liver, heart and kidney function, X-ray, CD4, CD8 cells were examined before and after treatment at 1, 3, 6 month. The patients were treated with 4 capsules t.i.d for 6 months.</p><p><b>RESULTS</b>The symptoms were improved in most of the patients, the CD4 cells increased from 115.0 to 295.2/ul and the viral load (RNA copies/ml) in most patients reduced markedly or maintained at the same level.</p><p><b>CONCLUSION</b>These data indicated that QuDu ZengNing Capsule was effective for treatment of AIDS patients.</p>